Simple Injector自发地无法注入部署到IIS的ASP.NET App

我面临着依赖注入（简单注入器）的问题，但它似乎只发生在将应用程序部署到运行IIS的服务器上，并且只有在它运行一段时间后才会发生 . 基于下面的StackTrace，似乎在依赖注入期间发生了NullReference异常 .

The interesting part is that if I restart the IIS Application, the application seems to continue working for some time. At a later point, presuming that no one has accessed the website, the following StackTrace is displayed:

[NullReferenceException：对象引用未设置为对象的实例 . ] DevOps.Data.DevOpsDbConnectionLoader.GetObjectInstanceInternal（程序集dbAssembly，String objectTypeName，Boolean isStatic）16 DevOps.Data.DevOpsDbConnectionLoader.GetEntityDbProviderServices（）156 NWatch.NWatchDbConfiguration..ctor （DevOpsDbConnectionLoader loader）239 NWatch.NWatchEntityApplication.Init（）429 BranchCircuits_Web.MvcApplication.RegisterTypes（Container container）298 BranchCircuits_Web.MvcApplication.Application_Start（）299 [HttpException（0x80004005）：对象引用未设置为对象的实例 . ]系统.Web.HttpApplicationFactory.EnsureAppStartCalledForIntegratedMode（HttpContext context，HttpApplication app）12601949 System.Web.HttpApplication.RegisterEventSubscriptionsWithIIS（IntPtr appContext，HttpContext context，MethodInfo [] handlers）175 System.Web.HttpApplication.InitSpecial（HttpApplicationState state，MethodInfo [] handlers， IntPtr appContext，HttpContext context） 304 System.Web.HttpApplicationFactory.GetSpecialApplicationInstance（IntPtr appContext，HttpContext context）404 System.Web.Hosting.PipelineRuntime.InitializeApplication（IntPtr appContext）475 [HttpException（0x80004005）：对象引用未设置为对象的实例 . ]系统 . Web.HttpRuntime.FirstRequestInit（HttpContext context）12618996 System.Web.HttpRuntime.EnsureFirstRequestInit（HttpContext context）159 System.Web.HttpRuntime.ProcessRequestNotificationPrivate（IIS7WorkerRequest wr，HttpContext context）12458613

Below is the Global.asax contents that is in charge for the dependency injection.

protected void Application_Start()
{
    AreaRegistration.RegisterAllAreas();
    GlobalConfiguration.Configure(WebApiConfig.Register);
    FilterConfig.RegisterGlobalFilters(GlobalFilters.Filters);
    RouteConfig.RegisterRoutes(RouteTable.Routes);
    BundleConfig.RegisterBundles(BundleTable.Bundles);

    var webApiContainer = new Container();
    webApiContainer.Options.DefaultScopedLifestyle = new WebApiRequestLifestyle();
    RegisterTypes(webApiContainer);
    webApiContainer.RegisterWebApiControllers(GlobalConfiguration.Configuration);
    webApiContainer.Verify();

    GlobalConfiguration.Configuration.DependencyResolver =
        new SimpleInjectorWebApiDependencyResolver(webApiContainer);
}

private void RegisterTypes(Container container)
{
    var virtualPath = HostingEnvironment.ApplicationVirtualPath.Substring(1);
    string baseName = null;

    if (!string.IsNullOrEmpty(virtualPath)) {
        baseName = HostingEnvironment.SiteName + "_" + virtualPath;
    } else {
        baseName = HostingEnvironment.SiteName;
    }

    var nWatchApp = new NWatchEntityApplication(GetNWatchConfig());
    Trace.Listeners.Add(new DevOps.Diagnostics.DevOpsLogTraceListener(baseName));
    container.RegisterSingleton<INWatchApplication>(nWatchApp);
    container.Register<NWatchDbContext>(() => nWatchApp.GetDbContext(), Lifestyle.Scoped);
}

private INWatchConfiguration GetNWatchConfig()
{
    Configuration rootConfig =
        System.Web.Configuration.WebConfigurationManager.OpenWebConfiguration(HostingEnvironment.ApplicationVirtualPath);
    return new NWatchSystemConfiguration(rootConfig);
}

有没有人在部署到IIS时遇到过这种情况？根本原因是什么，如何解决？